Ernesto Valverde's Bilbao team punished the visitors with clinical counter-attacks, playing with the advantage of having won the first leg 1-0 in Madrid.
Antoine Griezmann and Samuel Lino scored in each half to give Atletico Madrid a 2-0 win over Lazio on Wednesday that secured them top spot in Champions League Group E, the first time since 2016 that they had reached the knockouts as group winners.
The 19-year-old Mbappe followed up a domestic treble with Paris St Germain with a string of impressive performances in France's World Cup winning campaign.
It was, possibly, the biggest takeaway from France's victory. They can win when Mbappe does not shine or score, and his reaction to Giroud's goal proved Deschamps's point when he said he did not need to manage the Paris St Germain forward's ego.
Yet even though the Swiss lack world stars like France's Antoine Griezmann, Karim Benzema or Kylian Mbappe, Spain must be prepared for a long evening finding their way through Vladimir Petkovic's disciplined side on Friday in St Petersburg.
News of all that's transpired on and off the football field
Barcelona clinched a 1-0 away win at Atletico Madrid, while AS Roma held AC Milan to a 2-2 draw.
A round-up of Saturday's action in LaLiga, Ligue 1, Serie A and Bundesliga.
England coach Roy Hodgson, basking in a 2-1 victory over Wales on Thursday clinched by goals from two substitutes, said fringe players would be a major factor at Euro 2016. Gareth Bale put Wales in front before Jamie Vardy and Daniel Sturridge replied, the latter in stoppage time, after both came on in the second half. Hodgson said it was hard to remember if he had made a better double substitution in his 40-year career.
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Barcelona's Sergi Roberto and Robert Lewandowski struck just before halftime to give the league leaders a 2-0 home win over lowly Cadiz on Sunday in their pursuit of a 27th Spanish title.
Kylian Mbappe became France's youngest scorer at a World Cup when he put Les Bleus 1-0 ahead at halftime against Peru in their second Group C game on Thursday.
France coach Didier Deschamps was relieved to come through his side's 2-0 quarter-final win over Uruguay without losing any of his players to an unnecessary suspension, he said after Friday's match in Nizhny Novgorod.
Second-half strikes by Federico Valverde, Brahim Diaz and Endrick gave feeble Real Madrid an unconvincing 3-0 win over lowly Real Valladolid.
France was always among the favourites but an underwhelming set of warm-ups plus a timid start suggested their reputation rang louder than reality
The 19-year-old ravaged Argentina from start to finish in France's thrilling 4-3 win in Kazan
Tebas has led the campaign to get the season back on track since it was postponed on March 12, warning that clubs could lose up to one billion euros ($1.11 billion) collectively if the remaining 11 rounds of matches could not be completed.
Five images from last week's action in Europe for you to savour.
World champions France recovered from two goals down to beat Belgium 3-2 in a thrilling Nations League semi-final on Thursday with a last-minute strike from Theo Hernandez securing a place in Sunday's showpiece match against Spain.
Atletico Madrid made a typically aggressive start to lay the foundations for a 2-0 victory at home.
Uruguay captain Diego Godin praised his team mates as 'lions' after reaching the World Cup quarter-finals but falling 2-0 to France
Holders Barcelona crashed out of the Champions League after being stifled by a brilliantly well-organised Atletico Madrid.
The Video Assistant Referee (VAR) was used for the first time in a World Cup final to award France a 38th-minute penalty which Antoine Griezmann scored to give them a 2-1 lead over Croatia.
World champions France had eight players, one less than former holders Spain, in international players' association FIFPro's 55-name shortlist for its World XI of 2018 award.
Their limp performance does not inspire confidence ahead of the visit of the all-powerful Serie A leaders and familiar foe Cristiano Ronaldo.
The three match-ups which are likely to have a strong bearing on the result in Sunday's FIFA World Cup final.
Inter Milan captain Lautaro Martinez struck a last-gasp goal to snatch a dramatic 1-0 win over 10-man Napoli as they claimed their third successive Italian Super Cup title on Monday.
A rousing 2-1 La Liga victory at Real Madrid on Saturday may suggest otherwise, but Atletico Madrid are still rebuilding after losing several key players in the close season, coach Diego Simeone said on Monday.
Atletico Madrid have recorded five COVID-19 positives, including manager Diego Simeone
Real Madrid and Croatia midfielder Luka Modric was voted Player of the Year for last season by European soccer body UEFA on Thursday, ahead of Cristiano Ronaldo and Mohamed Salah with Lionel Messi fifth.
After tweaking his formation and starting lineup at Euro 2016, France coach Didier Deschamps seems to have found the perfect formula at just the right time. Thanks to his shrewd tactics, his team turned on the style to outplay Iceland 5-2 on Sunday and advance to an appetising semi-final battle with Germany. The fact that France, who had never got past the last eight at the finals since their 2000 triumph, managed to get almost everything right, has a lot to do with Deschamps' methods.
Antoine Griezmann headed two goals for Atletico Madrid in a 3-1 victory over Levante that kept them on the heels of La Liga leaders Real Madrid on Saturday.
Goalkeeping howlers have been scarce at the World Cup but Fernando Muslera's mistake proved fatal for Uruguay in their 2-0 quarter-final defeat by France on Friday just as much as a brilliant stop from Hugo Lloris kept his side ahead.
The quarter-final draw was the last in the current format with UEFA adopting an all-new format from the 2024-25 season onwards.
France showed the full range of their attacking weapons as they continued their preparations for the World Cup in convincing fashion with a 3-1 win over Italy in a friendly on Friday.
Girona reclaimed top spot in LaLiga after beating champions Barcelona 4-2
IMAGES from an exciting Europa League semi-final first leg match played at Emirates Stadium on Thursday
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Heavyweights Arsenal, Atletico Madrid and Lazio took big steps towards reaching the Europa League semi-finals after convincing home first-leg victories and RB Leipzig also stayed on course with a 1-0 win over Olympique de Marseille on Thursday.
The Tunisian captain's goal mobilised the French into action, with Deschamps bringing in stars like Kylian Mbappe and Antoine Griezmann to jump-start an attack that had so far been tepid.